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System Xcinhibitors such as erastin, sulfasalazine, sorafenib, and glutamateare considered class I ferroptosis inducers, and inhibition of System Xc - leads to compensatory transcriptional upregulation of SLC7A11 (65)
When used for skin whitening, glutathione is administered directly into the bloodstream via an IV infusion
Not all of these steps from oxidative attack to final hemolysis have been fully documented in vivo, in part because of one major difficulty: in the course of AHA the red blood cells sampled from the patient are obviously, at any given stage, those that have not yet hemolyzed
They have fewer side effects, such as allergic reactions, immunosuppression, and hypersensitivity